GLP-1 & Medical Weight Loss in South Dakota
86 clinics, medical spas, and weight-loss practices across 22 South Dakota cities — led by Sioux Falls, Rapid City, Brookings. 0 listings document GLP-1, medication, or peptide treatment directly; the other 86 are broader weight-loss and wellness practices, so confirm medication availability when you call. Statewide telehealth options are included below.
Providers
86
Cities Covered
22
Avg. Google Rating
4.7 ★
79 rated clinics
Telehealth Options
7
available statewide
Highest Rated
Top-rated weight-loss clinics in South Dakota
Ranked by Google rating weighted by review volume. Not every listing documents GLP-1 treatment — confirm current medication availability and pricing directly with the clinic.
Sioux Falls · Weight Loss Service · Medical Spa
5.0 · 365 reviews
Sioux Falls · Medical Spa · Health Spa
5.0 · 131 reviews
Sioux Falls · Weight Loss Service · Skin Care Clinic
5.0 · 125 reviews
SeraVia
Clinical GLP-1 Support
Clinically formulated to reduce nausea, fatigue, and GI issues during GLP-1 treatment.
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Compare GLP-1 prices before you pick a South Dakota clinic
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No Clinic Nearby?
Online GLP-1 providers serving all of South Dakota
These licensed telehealth companies evaluate you online and ship medication to any South Dakota address. Published pricing shown; verify current rates on their sites.
| Provider | Membership | Medication Cost | Pharmacy |
|---|---|---|---|
| Ro | $145/month | Starting at $149/mo | 503A |
| Hims | N/A | $134 | 503B |
| Mochi Health | $39/month | Compounded Semaglutide: $99/month or Compounded Tirzepatide: $199/month | 503A |
| Henry Meds | N/A | N/A | Undisclosed |
| Sesame | $50 | 149/month | Undisclosed |
| Form Health | $299 | $299 | 503A |
| Weight Watchers Clinic | $84-$149 | $84-$149 | Undisclosed |
What GLP-1 treatment costs in South Dakota
Most South Dakota clinics price GLP-1 programs one of two ways: a monthly membership that bundles the visit, medication, and follow-ups (typically $250–$500/month for compounded semaglutide, more for tirzepatide), or à-la-carte visit fees plus a pharmacy bill. Brand-name Ozempic, Wegovy, Mounjaro, or Zepbound without insurance coverage generally runs $900–$1,400 per month at retail.
Before committing, compare three things: who supervises treatment (physician, NP, or PA, and how often you're seen), where the medication comes from (a licensed 503A/503B compounding pharmacy or brand-name supply — ask for the pharmacy's name), and the all-in monthly cost at your maintenance dose, since many programs advertise a starting-dose price that rises as you titrate up.
In-person clinics in Sioux Falls, Rapid City, Brookings tend to include labs and body-composition tracking that telehealth skips; telehealth tends to win on price and convenience. Neither is categorically better — it depends on whether you want hands-on monitoring or the lowest sustainable monthly cost.
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All covered cities in South Dakota
GLP-1 in South Dakota: common questions
How much does semaglutide cost here?
Roughly $150–$500/month for compounded semaglutide through a clinic or telehealth provider depending on dose and program structure. Brand-name Ozempic or Wegovy without insurance typically runs $900–$1,400/month.
Can I get GLP-1s online in South Dakota?
Yes — licensed telehealth providers including Ro, Hims, Mochi Health, Henry Meds, and Sesame serve South Dakota residents with online evaluation and home delivery. See the comparison table above.
What should I ask a clinic before starting?
Who supervises treatment and how often you're seen; which pharmacy supplies the medication (name and 503A/503B status); the all-in monthly cost at your maintenance dose; and what happens with side effects or dose changes between visits.
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