GLP-1 Medications
Compare dosing, cost, side effects, and average weight loss across every GLP-1 medication available for weight management.
Quick Comparison
| Medication | Class | Dosing | Brand Cost | Compounded | Status |
|---|---|---|---|---|---|
| Semaglutide Ozempic, Wegovy, Rybelsus | GLP-1 | Once weekly (injection) or Once daily (oral) | $900-1,400 | $150-450 | Approved |
| Tirzepatide Mounjaro, Zepbound | GLP-1/GIP | Once weekly | $1,000-1,200 | $200-500 | Approved |
| Liraglutide Saxenda, Victoza | GLP-1 | Once daily | $1,300-1,500 (Saxenda); $900-1,100 (Victoza) | Not widely compounded | Approved |
| Dulaglutide Trulicity | GLP-1 | Once weekly | $900-1,100 | Not widely compounded | Approved |
| Exenatide Byetta, Bydureon | GLP-1 | Twice daily (Byetta) or Once weekly (Bydureon BCise) | $700-900 | Not widely compounded | Approved |
| Survodutide Pending FDA approval | GLP-1/Glucagon | Once weekly | Pricing not yet established | N/A | Phase 3 |
| Orforglipron Pending FDA approval | GLP-1 (Non-peptide, Oral) | Once daily | Pricing not yet established; expected to be significantly lower than injectable GLP-1s due to simpler manufacturing | Non-peptide molecule may be harder to compound | Phase 3 |
| Retatrutide Pending FDA approval | GLP-1/GIP/Glucagon | Once weekly | Pricing not yet established | N/A | Phase 3 |
All Medications
Semaglutide
Ozempic / Wegovy / Rybelsus
Semaglutide mimics the naturally occurring hormone GLP-1, binding to GLP-1 receptors in the pancreas to stimulate insulin secretion and suppress gluca...
Brand
$900-1,400
Compounded
$150-450
Tirzepatide
Mounjaro / Zepbound
Tirzepatide is a first-in-class dual incretin agonist that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. GLP-...
Brand
$1,000-1,200
Compounded
$200-500
Liraglutide
Saxenda / Victoza
Liraglutide is a GLP-1 analog with 97% homology to native human GLP-1. It binds to GLP-1 receptors to stimulate glucose-dependent insulin secretion, s...
Brand
$1,300-1,500 (Saxenda); $900-1,100 (Victoza)
Compounded
Not widely compounded
Dulaglutide
Trulicity
Dulaglutide consists of a GLP-1 analog covalently linked to a modified human IgG4 Fc fragment via a small peptide linker. This design reduces immunoge...
Brand
$900-1,100
Compounded
Not widely compounded
Exenatide
Byetta / Bydureon
Exenatide is a synthetic version of exendin-4, a peptide originally discovered in the saliva of the Gila monster (Heloderma suspectum). It shares 53% ...
Brand
$700-900
Compounded
Not widely compounded
Survodutide
Pending FDA approval
Survodutide is a dual agonist that activates both GLP-1 and glucagon receptors. GLP-1 activation reduces appetite, slows gastric emptying, and improve...
Brand
Pricing not yet established
Compounded
N/A
Orforglipron
Pending FDA approval
Orforglipron is a first-in-class oral non-peptide GLP-1 receptor agonist. Unlike oral semaglutide (Rybelsus), which is a peptide requiring absorption ...
Brand
Pricing not yet established; expected to be significantly lower than injectable GLP-1s due to simpler manufacturing
Compounded
Non-peptide molecule may be harder to compound
Retatrutide
Pending FDA approval
Retatrutide is a first-in-class triple incretin agonist that simultaneously activates three receptors: GLP-1 (appetite suppression, insulin secretion)...
Brand
Pricing not yet established
Compounded
N/A
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