Peptide Reference
MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA-c
A mitochondrial-derived peptide that regulates metabolic function. Known as an exercise mimetic that improves insulin sensitivity, increases fat oxidation, and enhances physical performance.
Status
research
Category
weight loss
Typical cost
$80-150/vial (10mg)
Mechanism
Translocates to nucleus and regulates metabolic genes. Activates AMPK pathway, improving glucose uptake and fatty acid oxidation. Enhances mitochondrial function and biogenesis.
Potential benefits
- Improved insulin sensitivity
- Enhanced fat oxidation
- Better exercise performance
- Metabolic flexibility
- Mitochondrial health
- Potential longevity benefits
- Enhanced insulin sensitivity
- Improved fat oxidation
- Better exercise capacity
- Metabolic regulation
- Potential longevity
Reported side effects
- Injection site reactions
- Mild fatigue
- Headache
- Sleep changes
- Limited human data
- Unknown long-term effects
Common dosing references
subcutaneous
5-10mg · 3x weekly
4-8 weeks
intranasal
1-2mg · Daily
4-8 weeks
subcutaneous
200-1000mcg · Daily
8-12 weeks
Research notes
MOTS-c as an exercise mimetic
2015
Demonstrated enhanced glucose uptake and fatty acid metabolism similar to exercise effects
MOTS-c and metabolic regulation
2015
Improved metabolic function and exercise capacity in animal models
MOTS-c AMPK activation
2016
Demonstrated AMPK pathway activation for metabolic benefits
Regulatory and sourcing notes
Research chemical only. Not FDA-approved. Under investigation for metabolic diseases.
Research peptide with limited suppliers. Verify mitochondrial peptide specialization. Often stacked with GLP-1s for metabolic enhancement.
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