Peptide Reference

Kisspeptin-54

Kisspeptin-54 (Metastin)

The full-length human kisspeptin with longer half-life than Kisspeptin-10. Used in clinical trials for reproductive medicine.

Status

clinical

Category

sexual

Typical cost

Clinical setting only

Mechanism

Same mechanism as Kisspeptin-10 but with longer duration of action. Activates kisspeptin receptors to stimulate GnRH and downstream reproductive hormones.

Potential benefits

  • Longer half-life than KP-10
  • Clinical trial data
  • Fertility restoration
  • Predictable response

Reported side effects

  • Requires IV administration
  • Medical supervision needed
  • Limited availability

Common dosing references

intravenous

Clinical setting only · Varies by protocol

Varies

Research notes

Kisspeptin-54 fertility trials

2014

Successful oocyte maturation in IVF protocols

Regulatory and sourcing notes

In clinical trials. Not FDA-approved. Used in research settings for fertility treatments.

Not available as research peptide. Used only in clinical trials and fertility clinics.

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