Peptide Reference
MK-677
Ibutamoren Mesylate
An orally active growth hormone secretagogue that mimics the GH-stimulating action of ghrelin. Non-peptide compound that increases GH and IGF-1 levels without injections.
Status
research
Category
growth hormone
Typical cost
$50-150/month
Mechanism
Acts as a ghrelin receptor agonist in the hypothalamus and pituitary, stimulating pulsatile GH release. Oral bioavailability makes it unique among GH secretagogues. Also increases appetite.
Potential benefits
- Increased growth hormone
- Oral administration
- Improved sleep quality
- Muscle preservation
- Fat loss
- Better recovery
- Increased bone density
Reported side effects
- Increased appetite
- Water retention
- Mild edema
- Numbness/tingling
- Reduced insulin sensitivity
- Lethargy
Common dosing references
oral
10-25mg · Daily
8-16 weeks
Research notes
MK-677 in healthy elderly
1998
Demonstrated sustained increases in GH and IGF-1 with good tolerability in 2-year study
Regulatory and sourcing notes
Research chemical only. Not FDA-approved. Investigated but never approved for clinical use.
Research chemical only. Quality varies widely. Third-party testing essential. Long half-life allows once-daily dosing.
Find peptide-aware clinics
Use location pages to compare clinics with peptide therapy signals and verify clinical oversight before treatment.
Related peptides