Peptide Reference
Ibutamoren (MK-677)
Ibutamoren Mesylate (MK-677)
An orally active growth hormone secretagogue that mimics ghrelin. Stimulates GH release and increases IGF-1 levels without cortisol elevation.
Status
research
Category
growth hormone
Typical cost
$50-100/month
Mechanism
Non-peptide ghrelin receptor agonist. Stimulates pulsatile GH release from pituitary. Increases IGF-1 without affecting cortisol levels significantly.
Potential benefits
- Oral administration
- Increased GH and IGF-1
- No cortisol elevation
- Improved sleep quality
- Muscle preservation
Reported side effects
- Increased appetite
- Water retention
- Mild edema
- Insulin resistance
- Numbness/tingling
Common dosing references
oral
10-25mg · Daily
12-24 weeks
Research notes
MK-677 GH stimulation
1998
Sustained increases in GH and IGF-1 over 12 months
MK-677 bone density
1999
Improved bone density in elderly subjects
Regulatory and sourcing notes
Research chemical only. Investigated by Merck for GH deficiency and osteoporosis. Not FDA-approved.
Research chemical. Popular for convenience of oral dosing. Long-term insulin resistance concerns.
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