Ibutamoren (MK-677)
Ibutamoren Mesylate (MK-677)
An orally active growth hormone secretagogue that mimics ghrelin. Stimulates GH release and increases IGF-1 levels without cortisol elevation.
Typical Cost
$50-100/month
Status
Research
Peptide Profile
Ibutamoren (MK-677)
Mechanism of Action
Non-peptide ghrelin receptor agonist. Stimulates pulsatile GH release from pituitary. Increases IGF-1 without affecting cortisol levels significantly.
Common Dosages
oral
10-25mg
Daily · 12-24 weeks
Benefits
Oral administration
Increased GH and IGF-1
No cortisol elevation
Improved sleep quality
Muscle preservation
Side Effects
Increased appetite
Water retention
Mild edema
Insulin resistance
Numbness/tingling
Key Research
MK-677 GH stimulation
Sustained increases in GH and IGF-1 over 12 months
MK-677 bone density
Improved bone density in elderly subjects
Regulatory Status
Research chemical only. Investigated by Merck for GH deficiency and osteoporosis. Not FDA-approved.
Contraindications
- ⚠Diabetes
- ⚠Active cancer
- ⚠Pregnancy/breastfeeding
GLP-1 users seeking GH optimization may prefer injectable peptides. SeraVia formulations support metabolic health.
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