Dulaglutide Dosing Schedule
Trulicity dosing from 0.75mg to 4.5mg weekly. Simple titration, hidden-needle pen, and no mixing required. Complete dosing guide.
Starting dose
0.75mg weekly
Maximum dose
4.5mg weekly
Dose options
4 (0.75-4.5mg)
Delivery
Hidden-needle pen
Injection time
~5 seconds
Standard Titration
Dulaglutide follows a simple titration: Start at 0.75mg once weekly for at least 4 weeks. Increase to 1.5mg once weekly. If additional glycemic control is needed, increase to 3.0mg after at least 4 weeks, then to 4.5mg after at least 4 more weeks.
The 0.75mg starting dose provides some therapeutic benefit (unlike the purely initiation doses of semaglutide and tirzepatide), so patients may notice blood sugar improvements from the start.
The Trulicity Pen
Trulicity uses a pre-filled, single-dose pen with a hidden needle. There's no need to attach needles, mix medication, or see the needle at any point. Press the pen against your skin, push the green button, and the injection is delivered automatically.
This device design is particularly valued by patients with needle phobia. The entire injection process takes about 5 seconds. Rotate injection sites between abdomen, thigh, and upper arm.
Missed Doses
If you miss a Trulicity dose and the next scheduled dose is more than 3 days away, take the missed dose as soon as possible. If the next dose is within 3 days, skip the missed dose and resume your regular schedule. Do not double up on doses.
Frequently Asked Questions
How do you use the Trulicity pen?
Unlock the gray base cap, place the clear base flat on your skin, press and hold the green button for ~5 seconds until you hear a click. The needle is hidden throughout -- you never see or handle it.
What if I miss a Trulicity dose?
If your next dose is more than 3 days away, take the missed dose now. If within 3 days, skip it and resume your normal schedule.
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