Constipation
Infrequent or difficult bowel movements, often with hard or dry stools
Prevalence
15-25% of patients
Severity
Very Common
Category
Gastrointestinal
Why It Happens
GLP-1 agonists significantly slow gastric emptying and can reduce overall gut motility. Combined with reduced food intake (from appetite suppression), there is less bulk moving through the intestines. Reduced fluid intake can worsen the effect.
Timeline
Can begin within the first few weeks of treatment. May persist longer than other GI side effects because reduced food intake continues throughout treatment. Often manageable with dietary adjustments.
Management Tips
Increase water intake to at least 64 oz (2 liters) per day
Add fiber-rich foods gradually (fruits, vegetables, whole grains)
Consider a fiber supplement like psyllium husk (Metamucil)
Stay physically active — regular walking helps stimulate gut motility
Try a magnesium citrate supplement (consult your doctor first)
Establish a regular bathroom routine
Avoid excessive use of stimulant laxatives
When to See Your Doctor
If you have not had a bowel movement in more than 3 days, experience severe abdominal pain or bloating, notice blood in your stool, or if over-the-counter remedies are not effective
Medications That May Cause Constipation
SeraVia GLP-1 Support
Contains magnesium and prebiotic fiber to promote healthy digestion and regularity
Learn More →Constipation FAQs
Why does Ozempic cause constipation?
GLP-1 medications slow the movement of food through your entire digestive tract (delayed gastric emptying). Combined with eating less food overall due to appetite suppression, there is less material and less motility to produce regular bowel movements.
What is the best laxative to take with GLP-1 medication?
Osmotic laxatives like MiraLAX (polyethylene glycol) or magnesium citrate are generally well-tolerated. Fiber supplements like psyllium husk can also help. Avoid relying on stimulant laxatives long-term. Always check with your doctor before starting any laxative.
Is constipation from GLP-1 medications permanent?
Not usually. Many patients find improvement with adequate hydration, fiber intake, and physical activity. Your body may also partially adapt over time. If constipation persists, your doctor can recommend specific treatments.
Talk to a provider about managing constipation
If constipation is affecting your quality of life, a qualified provider can adjust your dose or recommend management strategies.
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