Which GLP-1 medication is most affordable?

Affordability depends heavily on insurance coverage and available assistance programs, not just list price. Liraglutide (Saxenda) has the lowest cash price at approximately $1,200-1,400/month but requires daily injections. Semaglutide and tirzepatide both list around $1,300-1,600/month without insurance. Novo Nordisk and Eli Lilly offer patient assistance programs covering medications for qualifying low-income uninsured patients. Manufacturer coupons can reduce copays to $25/month for commercially insured patients. Compounded semaglutide from reputable 503A pharmacies costs $200-500/month but lacks insurance coverage. Medicare patients face the most challenges as weight loss medications aren't covered under Part D, though diabetes indications may qualify.