What role does exercise play in GLP-1 weight loss?

While GLP-1 medications produce weight loss without exercise, physical activity significantly enhances results and preserves muscle mass. Exercise increases the calorie deficit beyond medication-induced appetite suppression. Resistance training is crucial for maintaining lean body mass during rapid weight loss - aim for 3-4 sessions weekly targeting major muscle groups. Cardiovascular exercise improves insulin sensitivity and cardiovascular health. The combination of GLP-1s plus exercise produces better body composition changes than either alone. Exercise also helps prevent weight regain if medication is stopped. Start with manageable activities and increase intensity gradually. Even walking 30 minutes daily provides meaningful benefits. GLP-1 medications may increase energy levels as weight decreases, making exercise more accessible over time.