What is the average weight loss after 3 months on semaglutide?

Clinical trials show average weight loss of 6-8% of body weight after 3 months on semaglutide 2.4mg (Wegovy). For a 220-pound person, this represents approximately 13-18 pounds. By the 3-month mark, most patients have reached the 1.0mg or 1.7mg dose level following standard titration protocols. Real-world results often match or exceed clinical trial data, with some patients losing 10-15% by month 3 if they tolerate rapid titration well. Weight loss typically accelerates during months 2-4 as higher therapeutic doses are reached. Patients who also implement dietary modifications and increase physical activity may see greater results than medication alone.