How much weight will I lose after 6 months on tirzepatide?

The SURMOUNT-1 trial showed average weight loss of 15-20% after 6 months on tirzepatide at the 10mg and 15mg doses. For a 250-pound individual, this represents 37-50 pounds. Tirzepatide generally produces faster weight loss than semaglutide due to its dual GLP-1/GIP mechanism. By month 6, most patients have reached their maximum tolerated dose and are in the active weight loss phase. Some patients achieve 20-25% weight loss in this timeframe, particularly those with higher starting BMIs. The rate of weight loss typically begins to slow after month 6 as the body adapts metabolically and approaches a new set point.