How much weight can I expect to lose in the first month on GLP-1 medications?

Most patients lose 3-5% of their body weight during the first month on GLP-1 medications like semaglutide or tirzepatide. For a 200-pound person, this translates to 6-10 pounds. Early weight loss is often more rapid due to reduced appetite, lower calorie intake, and water weight reduction from improved glycemic control. However, individual results vary significantly based on starting weight, adherence to dosing schedule, dietary changes, and physical activity. Some patients lose more quickly in weeks 1-4, while others see slower initial progress that accelerates as doses increase. The first month typically involves the lowest starting doses (0.25mg semaglutide or 2.5mg tirzepatide), so more substantial weight loss usually begins in months 2-3 as titration progresses.